Those of us with chronic Lyme disease are quite familiar with the names of the better known Lyme co-infections. Babesia, Bartonella, and Ehrlichia have become everyday words. As much as we would like to rid ourselves of these illness-producing pathogens, they have become a part of our daily struggle to regain a sense of health and wellness. Unfortunately, these are not the only co-infections seen in chronic Lyme disease. For some reason, Mycoplasma infections are not only lesser known by patients, but seemingly often overlooked by doctors as well. It is important for us, as patients, to educate ourselves on the topic of Mycoplasma and to ask our practitioners how we are being evaluated and treated for these infections.
In 1987, Dr. Garth Nicolson, PhD was a professor
at the University of Texas at Houston when his wife, an instructor at
Baylor College of Medicine, became seriously ill and nearly died. She
was diagnosed with a
Mycoplasma infection, treated, and later recovered. A few years
later, their daughter, who had served in the Gulf War, returned from
active duty quite ill. Not only was she sick, but the symptoms that she
exhibited were very similar to those that Dr. Nicolson's wife had
expressed years earlier.
At that point, Dr. Nicolson had the idea that his daughter's illness
could be the result of an infection and started to investigate his
theory further. As his work progressed, he looked at
Brucella, Borrelia, Ehrlichia, and other chronic intracellular
infections that have the potential to cause illness and present with
overlapping signs and symptoms. In Gulf War veterans that were being
evaluated, approximately 45% of those that were ill had Mycoplasma
infection. It was found that the infection was a particular type of
Mycoplasma, namely a peculiar species called Mycoplasma fermentans.
Very little was known about this particular species of Mycoplasma
at the time except that the Armed Forces Institute of Pathology and the
Army had been doing research on the organism. Once this likely
causative agent of Gulf War Illness (GWI) had been identified in about
one-half of the GWI cases, Dr. Nicolson recommended that the
Mycoplasma-infected Gulf War veterans be treated with
Doxycycline. He then found himself the target of vicious attacks for
making the connection between the illness and
M. fermentans. Dr. Nicolson shared that "even talking about
this organism was highly discouraged." In fact, until the Gulf War, the
military's own medical school had been teaching about the dangers of
M. fermentans for years.
Just years earlier in Texas, prisons emerged in which many of the
inmates and guards came down with neurodegenerative conditions at rates
that were far from ordinary. In Huntsville, where three large State
prisons are found, there were about 70 cases of ALS, numerous cases of
Multiple Sclerosis, and highly unexpected numbers of Rheumatoid
Arthritis cases. At that time, the term "Mystery Disease" was used to
identify the unusual illnesses that so many seemed to have acquired.
Dr. Nicolson started testing prison guards and their family members and
found that very high numbers of these people were testing positive for
Mycoplasma fermentans. Furthermore, this appeared to be a weaponized version of the organism called
M. fermentans incognitus, a specific strain of Mycoplasma
that had been altered to cause more severe symptoms, to be more
virulent, and to be more survivable than the naturally occurring M.
fermentans. Dr. Nicolson believed that biological weapons experiments
had been carried out on inmates in the Texas prison system for years in
which humans had been used as guinea pigs.
As time progressed, these illnesses did not
remain confined to the prisoners. Soon after the prisoners unknowingly
became a part in these experiments, the prison guards became ill. Their
illnesses gradually became those of their families. It was not long
Mycoplasma-based illnesses became a broader part of the surrounding Huntsville, Texas landscape.
The Texas prisoners that came down with Amyotrophic Lateral Sclerosis
(ALS) later died. In the state of Texas, at the time, the state law
dictated that all prisoners that died were later to be autopsied at
University of Texas at Galveston. However, that was not what was
happening to the prisoners who had died as a result of this horrific
experimentation, according to Dr. Nicolson. Through one of his former
students who at the time was responsible for the autopsy service at UT
Galveston, Dr. Nicolson learned that none of the bodies had been sent
there. Dr. Nicolson had discovered that at least six private autopsies a
week were being performed on deceased prisoners at a US Army base. The
bodies were then sent to a private crematory at a secret location in
central Texas. Additionally, prisoner records were destroyed. All of
this, according to Dr. Nicolson, violated state law.
Though much of the evidence of this experimentation had been destroyed,
a document was found in the basement of an Austin building that was
viewed as the "smoking gun". The document indicated that the Texas
Prison Board, Baylor College of Medicine, and the Department of Defense
were all a part of the experiments involving the Texas prisoners -
experiments that later resulted in the death of many of the inmates.
According to Dr. Nicolson, some of the experiments used
Mycoplasma while others utilized various "cocktails of microbial agents" such as
Mycoplasma, Brucella, and DNA viruses such as Parvovirus B19. This project later became the topic of a book by Dr. Nicolson entitled
Project Day Lily.
Dr. Nicolson believes that Mycoplasma fermentans is a
naturally occurring microbe. However, some of the strains that exist
today have been weaponized. Dr. Nicolson's research found unusual genes
M. fermentans incognitus that were consistent with a weaponized
form of the organism. Weaponzing of an organism is done in an attempt
to make a germ more pathogenic, immunosuppressive, resistant to heat and
dryness, and to increase its survival rate such that the germ could be
used in various types of weapons. Genes which were part of the
HIV-1 envelope gene were found in these Mycoplasma. This means that the infection may not give someone
HIV, but that it may result in some of the debilitating symptoms of the HIV
disease. Indicators of a weaponized organism were evident in the
prison guards in Huntsville as well as in military personnel that were
likely exposed to the infections both through military vaccinations as
well as through weapons used in the Gulf War.
The unfortunate reality according to Dr. Nicolson is that "once these
things get out, you can't put the genie back in the bottle". Once
these germs have been released, they are airborne infections that slowly
penetrate into the population. In the case of
Mycoplasma fermentans, Dr. Nicolson believes that this is exactly what happened. It may be this weaponized form of
Mycoplasma that has led to the significant increases in
neurodegenerative and autoimmune diseases over the last several years.
Those patients with weaponized strains of these organisms are generally
very sick. They may experience 60-75 signs and symptoms and are even
at risk of their diseases becoming fatal.
In looking at the source of infection in the Gulf War veterans who were contracting
Mycoplasma, Dr. Nicolson suggests that vaccinations appear to be
the most likely mechanism through which the veterans became infected.
Many military personnel that later became ill were far from the
battlefields or had received the vaccinations and were never deployed.
However, biological weapons sprayers were known to have been deployed by
the Iraqis in the Gulf War and were used to spray the sand in Iraq and
Kuwait. Gerald Schumacher, a Special Forces colonel in charge of
biological weapons detection, blew the whistle on this after he retired.
During the Gulf War, his group was not allowed to deploy their
biological weapons detectors which led to reports that no such weapons
were detected or used.
The Iraqis received a great deal of assistance on
biological warfare from the United States during the Iran-Iraq
Conflict. Both chemical and biologic weapons were given to them from
the United States. After the Gulf War, rather than taking inventory of
these weapons, they were blown up. Dr. Nicolson indicates that some of
his patients have taken videos standing next to crates with Hazardous
Materials tags from the United States. In the same videos, the crates
are opened and weapons are clearly striped as having originated from the
United States and being both chemical and biological weapons.
There were clear indicators that Iraq had offensive weapons in their
arsenal. In Kuwait, many people had become quite ill. It was estimated
that 25% of the population after the Gulf War had signs and symptoms
which matched the symptoms of those infected with weaponized
Mycoplasma. There were also a number of other chemical exposures
and thus, there was never a clear indicator as to whether or not the
Iraqi illnesses were caused by biologic or chemical agents.
When asking Dr. Nicolson how much he personally has been harassed for
bringing much of this information to light, he shared that it has been
"a horrific time". After Dr. Nicolson exposed the Huntsville prison
experiments, the University of Texas educational system attempted to
fire him from his tenured and highly respected position. Dr. Nicolson
shared that a tremendous amount of pressure was put on the University of
Texas system to "shut him up and close his laboratory". He was
threatened on an almost daily basis with closing his lab as he continued
to do his research on Mycoplasma. This became a major subject in the
Project Day Lily. Fortunately, for many of us struggling with
chronic illnesses, Dr. Nicolson's experience and knowledge continue to
be a benefit in that we understand so much more than we otherwise would
about this formidable foe called
The signs and symptoms of Mycoplasma infection are highly
variable and thus it is not uncommon for a diagnosis to be entirely
missed. A partial list of symptoms includes chronic fatigue, joint
pain, intermittent fevers, headaches, coughing, nausea, gastrointestinal
problems, diarrhea, visual disturbances, memory loss, sleep
disturbances, skin rashes, joint stiffness, depression, irritability,
congestion, night sweats, loss of concentration, muscle spasms,
nervousness, anxiety, chest pain, breathing irregularities, balance
problems, light sensitivity, hair loss, problems with urination,
congestive heart failure, blood pressure abnormalities, lymph node pain,
chemical sensitivities, persistent coughing, eye pain, floaters in the
eyes, and many others. On Dr. Nicolson's web site at
http://www.immed.org, a full list of signs and symptoms and an illness
survey form can be found.
It doesn't take long to see that the symptoms of Mycoplasma infections are very similar to the symptoms of
Borrelia infections in chronic Lyme disease. Dr. Nicolson has
looked at some of the more common neurodegenerative diseases and the
infections that are associated with each. Mycoplasma is commonly
found in patients with ALS, Multiple Sclerosis, Autism, Chronic Fatigue
Syndrome, Rheumatoid Arthritis, Chronic Asthma, Lyme disease, and many
other chronic disease conditions.
Mycoplasma are pleomorphic bacteria which lack a cell wall and,
as a result, many antibiotics are not effective against this type of
bacteria. There are over 100 known species of
Mycoplasma, but only a half dozen or so are known to be
pathogenic in humans. The pathogenic species are intracellular and must
enter cells to survive. Once they are inside the cells, they are not
recognized by the immune system and it is difficult to mount an
They stimulate reactive-oxygen species (ROS) which damage cell
membranes. They release toxins into the body. Infected cells can be
stimulated to undergo programmed cell death which may result in ALS or
other severe neurological presentations. 90% of ALS patients evaluated
were found to have Mycoplasma infections, whereas
Mycoplasma was found in 100% of ALS patients with Gulf War Syndrome, almost all of which were weaponized
M. fermentans incognitus.
They are thought of as "borderline anaerobes", meaning that they
generally prefer low oxygen environments. Dr. Nicolson has found that
airline employees are much more susceptible to these types of infections
and that symptoms worsen with frequent long flights at low oxygen
Mycoplasma also have some characteristics of viruses.
Mycoplasma tend to be slow growing infections and they are usually transmitted slowly. Dr. Nicolson states that
"Mycoplasma can be sexually transmitted, but the infection is usually passed through far less intimate contact.
Mycoplasma can be obtained through fluid exchange, and it is
easily transmitted through the air." In Gulf War veterans, the first
person besides the veteran to become ill was the spouse and, later,
other members of the household also became ill. Not everyone is equally
Mycoplasma infections, especially those with strong immune systems who can resist infection.
As already discussed, Mycoplasma fermentans produces numerous symptoms. Those infected are rarely found to be asymptomatic. In North America,
M. pneumoniae is the most common Mycoplasma seen in various diseases. In Europe,
M. hominis is far more prevalent and the incidence of M. fermentans is much lower than in North America.
The potential genetic factors involved in Mycoplasma
illnesses are not known. Those with immune deficiencies and other
illnesses, such as cancers and degenerative diseases, are at far greater
risk of infection.
In one study looking at Mycoplasma in patients with Chronic
Fatigue Syndrome, Dr. Nicolson has observed some interesting patterns in
his research. Generally, the majority of CFS patients have
Mycoplasma infections. However, CFS patients infected with Borrelia
burgdorferi, the punitive agent in Lyme disease, had an even higher overall Mycoplasma infection rate. As many as 75% of Lyme disease patients appear to have
Mycoplasma infections, and yet Mycoplasma is often
overlooked in the diagnosis and treatment of chronic Lyme disease,
neurodegenerative diseases, and many other chronic illnesses lacking
Even more startling was the finding that of the patients infected with Borrelia, over 50% of the patients had the
M. fermentans infection. Approximately 23% carried M. pneumoniae.
Chronic Fatigue patients that did not test positive for Borrelia had much more of a mixture of various species of
Mycoplasma. Only 28% of the group not co-infected with Lyme disease had the
M. fermentans infection. In normal, healthy controls, only 1.7% were found to have
M. fermentans and at a total Mycoplasma infection rate of 5% compared to the 75% group mentioned earlier.
Dr. Nicolson notes that these findings are consistent with the fact that it is the
Mycoplasma fermentans species that is more often isolated in ticks collected from the environment. The same tick that serves as the vector for
Borrelia burgdorferi often also transmits M. fermentans simultaneously. Once a patient is multiply co-infected, the duration and severity of their illness both increase.
In his experience, Dr. Nicolson has found that Mycoplasma is the number one Lyme coinfection. The rate of infection with
Mycoplasma in patients with Lyme disease surpasses that of Bartonella (25-40%) slightly and that of
Babesia (8-20%) significantly.
According to Dr. Nicolson, a healthy immune system can generally clear M. pneumoniae infections though will have a harder time eradicating
M. fermentans on its own. Healthy people can often hold these
infections in check - essentially having the infection but not
Dr. Nicolson noted that Mycoplasma infections in chronic Lyme
disease are often overlooked by most doctors because they simply don't
test for it. He states that those that do test for it find a much
higher number of infected patients. Dr. Richard Horowitz, MD in New
York finds a high incidence of
M. fermentans, according to Dr. Nicolson.
Sadly, however, even if patients are tested for Mycoplasma, a
similar problem exists here as the one that almost all Lyme doctors and
patients are aware of - namely that reliable tests do not exist. Dr.
Nicolson notes that once a laboratory gets a reliable test in place, the
laboratory is often shutdown. There are only a few labs left that test
Mycoplasma as a result.
In testing ticks for various microbial species, Dr. Nicolson has found a very high incidence of
Mycoplasma fermentans. However, other Mycoplasma species have also been found such as
M. pneumoniae and M. hominis. The incidence of these other species is far lower. "Far and away", it is the
M. fermentans species that is seen in ticks, and this probably reflects the high incidence of
M. fermentans coinfections in Lyme disease.
In terms of laboratory testing, Dr. Nicolson generally recommends Viral
Immune Pathology, formerly known as RedLabs. He has found that the
usefulness of any given lab in testing for Mycoplasma changes regularly.
In the past, Dr. Nicolson used Medical Diagnostic Laboratories (MDL)
for testing, but later he and other physicians found that the testing
was no longer reliable. As a result, he no longer recommends
Dr. Nicolson finds that laboratories testing for Mycoplasma are highly scrutinized by federal agencies and that may affect the way the labs test and report this type of infection.
Thomas McPherson Brown, MD studied Mycoplasma at the
Rockefeller Institute just before World War II. He was able to isolate
bacteria from the joint fluid of a person with autoimmune arthritis and
believed that the infection could have been the trigger for her disease.
At the time, the organisms were too small to identify precisely, but
it was later determined to be
Even then, Dr. Brown believed that Mycoplasma was very common and not
easy to eradicate. He suggested using tetracycline drugs as an
effective treatment for the disease. He later found that Doxycycline
and Minocycline were effective at dealing with
Mycoplasma. Though he garnered praise from his patients, he was
generally regarded by the medical community as misguided and a
trouble-maker. He died in 1989 prior to being fully vindicated.
Fortunately, his work was validated through an NIH-sponsored study
called MIRA or "Minocycline in Rheumatoid Arthritis".
Due to many of the characteristics of Mycoplasma, they may be responsible for the triggering of numerous autoimmune responses. As
Mycoplasma replicate within cells and are eventually released,
they capture antigens from the surface of the host cell and incorporate
these antigens into their own membranes. This makes it almost
impossible for the body to tell the difference between good and bad,
between human and microbe, or between us and them. As a result, the
immune system may begin to respond to these antigens now incorporated
into the cell walls of the bacteria and create a condition of
self-attack, or autoimmunity.
The microorganisms can produce mimicry antigens that mimic the natural
host surface antigens and trigger an immune response to these antigens
which may also result in autoimmune conditions through cross-reactivity.
Mycoplasma may cause cell death of host cells through a process known as apoptosis or programmed cell death.
Though various strains of Mycoplasma have their own unique
characteristics and drug responses, treatment tends to be quite similar.
The variations in the strains do not appear to be a factor in a
successful treatment response.
Dr. Nicolson suggests that in-vitro differences have been found but
that it is not possible to easily extrapolate these findings to an
in-vivo environment. Various factors including drug targeting, drug
clearance, and the ability for the drug to cross into various body
compartments are important considerations in treatment that cannot be
Dr. Nicolson believes that, like many other coinfections of Lyme disease,
Mycoplasma cannot be fully eradicated, but that once infected,
treatment becomes an ongoing "management approach". He notes that this
is a commonly understood fact and that the same is true of other
organisms such as
Chlamydia and Borrelia. Mycoplasma have the
ability to go into a quiescent phase in intracellular locations within
the body. Once in these locations, neither antibiotics nor the immune
system can effectively reach or kill the organisms.
Many people recover from Mycoplasma
infections and are fine for years. They may later have an incident
involving severe trauma or other significant life stressor and symptoms
fully reappear within weeks to months.
Dr. Nicolson recommends that the physician adopt
an initial 6-month course of treatment with no break followed by several
6-week on, 2-week off antibiotic cycles. Candidate antibiotics
include: Doxycycline, Ciprofloxacin (Cipro), Azithromycin (Zithromax),
Minocycline, or Clarithromycin (Biaxin). He notes that antibiotic
combinations may be required if there is a limited response to single
drug, and most patients require switching antibiotics at least once
during their treatment. Some patients may find the addition of Flagyl
to be a benefit to treatment.
In Gulf War patients, once effectively treated,
the majority of patients recovered. For civilians, six months is the
minimum recommended treatment length, and some patients require much
longer treatment in order to recover.
Given that Mycoplasma have some
characteristics of viruses, some physicians have suggested that Famvir
or Ganciclovir may be added to the antibiotic therapy.
Herxheimer reactions do occur when treating Mycoplasma
infections. To minimize this die-off effect where the patient generally
feels much worse while on treatment, Dr. Nicolson advises using 50mg
oral Benadryl taken 30 minutes before the antibiotics. He also finds
that a strained blend of 1 whole lemon, 1 cup fruit juice, and 1
tablespoon of olive oil can be helpful.
Though Dr. Nicolson believes that antibiotics are
the most effective approach to treating Mycoplasma infections, he has
found some good natural options. In terms of natural approaches to
Mycoplasma, Raintree Nutrition (http://www.rain-tree.com) has
created several products that may be quite helpful for patients. These
include Raintree Myco, Raintree A-F, and Raintree Immune Support.
Dr. Nicolson has seen evidence that Mycoplasma-specific transfer
factors such as those from Chisholm Labs and others can be beneficial
in some patients. He says that many natural options help in some
patients, but that his experience has been that the antibiotic treatment
results in the best outcomes. In many, recovery requires a push and
pull between conventional and alternative treatments.
One of the hallmark signs of Mycoplasma infection is fatigue.
The infections lead to oxidation in the body that leads to damage of the
cell membranes. Oxidation accelerates the damage to the lipids in cell
membranes which impacts mitochondrial function. This leads to less
energy in the cell and ultimately to a fatiguing of the larger organism
due to the fact that there is less energy to support necessary cellular
In patients where fatigue is due to cell membrane
damage, Dr. Nicolson has found NT Factor® to be highly beneficial. NT
Factor® replaces the damaged lipids and helps to restore mitochondrial
function. Often, fatigue then resolves or is reduced.
Dr. Nicolson has found that oxidative therapies such as ozone can be helpful in the fight against
Mycoplasma. However, he notes that this is generally palliative
and does not produce the same results as the antibiotic therapy in the
long-term. He finds that the oxidative therapies "are generally more
cytostatic than cytotoxic". Hyperbaric oxygen may be helpful but
similarly does not appear to be a highly effective treatment in the
In other countries, IV drips with H2O2 (hydrogen peroxide) have been
used with some benefit, but Dr. Nicolson notes that these therapies,
while potentially effective, are highly dangerous and not advised.
In the realm of frequency medicine and Rife therapy, Dr. Nicolson believes that the frequencies that could be used to address
Mycoplasma are too similar to normal cellular frequencies.
Thus, he is not certain that Rife therapy is an effective way to
approach the problem.
In the nutritional realm, Dr. Nicolson finds that many patients with
chronic infections are immunosuppressed and that proper nutrition is
vital. He cautions against smoking and drinking. He suggests avoidance
of sugars, trans-fats, and
allergenic foods. He advises patients to increase their fruits,
vegetables, and whole grains. Some dietary winners in supporting the
immune system include cruciferous vegetables, soluble fiber-based foods
such as prunes and bran, wheat germ, yogurt, fish, and whole grains.
Patients are often depleted in key vitamins and
minerals. Supplementation with B-Complex, Vitamin C, Vitamin E, and
CoQ-10 are often beneficial. Minerals are often necessary. Dr.
Nicolson notes, however, that many people have poor absorption and may
require sublingual or injectable forms of these nutrients. Amino
acids, flax seed, and fish oils can provide additional support, but the
best nutrition for cell membranes is NT Factor®.
Many patients with chronic illnesses have a toxic body burden of heavy
metals such as mercury, lead, cadmium, and aluminum. Hair, stool, and
urine testing is available through labs like Doctor's Data
(http://www.doctorsdata.com) and Genova Diagnostics
(http://www.gdx.net). Dr. Nicolson has seen reports of positive results
with EDTA chelation suppositories from Detoxamin
(http://www.detoxamin.com) and oral chelators from Longevity Plus
For patients using antibiotics, beneficial gut flora is often
depressed. Supplementation with a high quality probiotic is important,
but probiotics have to be taken two hours or longer after taking
antibiotics. Natural immune support can be helpful in the form of
whey proteins, transfer factors, or immune-support products such as
Beyond Immuni-T from Longevity Plus.
Dr. Nicolson believes that biofilms are a factor in successfully treating Mycoplasma infections. In cases that are refractory to antibiotics, biofilms are likely a major factor.
In men with chronic refractory prostatitis which is infection-based,
one often cannot be treated effectively with antibiotics. However, when
Detoxamin (EDTA) or other agents to address the biofilms are used, it
then becomes possible to treat these infections with tetracyclines.
Patients quickly show functional increases and decreases in pain other
In chronic Lyme disease, it is often difficult to know which infections
are actually responsible for the persistence of illness. However, in
general terms, chronic intracellular infections that change the
metabolism of cells and suppress mitochondrial and other functions will
lead to patients remaining in a chronically ill state. Dr. Nicolson
believes that these infections must be aggressively treated. "Similar
to chronic Lyme disease, the current CDC or IDSA recommendations for
short-term treatment of chronic infections are simply inadequate," he
Dr. Nicolson has found that there is a hierarchy
of symptoms that resolve relatively quickly and those that resolve more
slowly when treating
Mycoplasma. Gut-associated phenomenon such as Irritable Bowel
Syndrome (IBS) often resolve quickly. Other systemic signs and
symptoms can resolve in an intermediate period of time from many weeks
to many months. Symptoms associated with the central and peripheral
nervous systems such as neuropathy and pain often resolve much more
slowly. Skin sensitivity and burning sensations may take much longer to
Mycoplasma infections do invade nerves, and nerve-related symptoms are among the more difficult to resolve.
Dr. Nicolson states "We keep seeing the suppression of information on Mycoplasma and similar intracellular bacterial infections. The world of
Mycoplasma parallels the world of chronic Lyme disease in terms
of the politics involved. Physicians are being persecuted by their
medical boards as a result of bad information. It is important for us
to do everything within our power to get rid of harmful, erroneous
information about these diseases. Both
Mycoplasma and Borrelia have been manipulated for
biological weapons purposes and as a result, both are politically
incorrect to discuss, work on, or do anything about. Until this
changes, we won't see any real progress."
Scott Forsgren is the editor and founder of the website
BetterHealthGuy.com where he shares his twelve year journey through a
chronic illness only diagnosed as Lyme disease after eight years of
searching for answers. Scott can be reached at
Additional information on NT Factor® can be found at
www.ntfactor.com or www.researchednutritionals.com.